Where to watch the 49ers vs. Chiefs game: TV channel, NFL kickoff time, live stream, spread, odds

In the Kyle Shanahan-led San Francisco 49ers’ fight to overcome the hurdle and win the Super Bowl, there was one constant: every time they came close to laying their hands on the Lombardi Trophy for the first time since 1994, the The Kansas City Chiefs stood in their way.

With three Super Bowls since 2019, the Chiefs have built much of their dynasty on the backs of the 49ers as they defeated San Francisco in both Super Bowls LIV and LVIII. Both were epic contests — particularly last year’s Super Bowl, in which the two teams played nearly a full quarter of overtime before Kansas City delivered the final blow — and both robbed the 49ers of a championship the Bay Area is so desperate for longs. With the Chiefs aiming for third place in the league this season, Kansas City is once again standing in the way of San Francisco’s Super Bowl ambitions. But this weekend they have a chance to take a step in that direction as the 49ers host the Chiefs in Northern California.

While a win over the Chiefs can’t really avenge the 49ers’ recent Super Bowl loss, a victory over the 0-5 Chiefs can go a long way toward proving that this year’s team has what it takes to be the greatest Game to return from everyone. While the 49ers are just 3-3, they enter this game with an NFC West division win over the Seattle Seahawks and are in position to take control of their division by going over .500.

Where to watch 49ers vs. Chiefs?

• When: Sunday, October 20 at 4:25 p.m. ET
• Where: Levi’s Stadium – Santa Clara, California
• TV: FOX
• Streaming: fuboTV (Try for free. Regional restrictions may apply.)
• Consequences: CBS Sports App

49ers vs. Chiefs distribution, odds

According to the latest NFL odds, San Francisco is a slight 1.5-point favorite against Kansas City. The over/under is 47 points.

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49ers vs. Chiefs current series history

Can you imagine a shorter, more meaningful and more one-sided story? Patrick Mahomes was drafted in 2017. He has faced the 49ers four times – including twice in the Super Bowl – and is 4-0. In case you’re wondering, San Francisco’s last win against Kansas City was on October 5, 2014, when the 49ers won 22-17.

• February 11, 2024 – Kansas City 25, San Francisco 22
• Oct. 23, 2022 – Kansas City 44, San Francisco 23
• February 2, 2020 – Kansas City 31, San Francisco 20
• September 23, 2018 – Kansas City 38, San Francisco 27