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LSU vs Arkansas Prediction, Picks, Spread, Odds for Football Matches, Where to Watch, TV Channel, Live Stream

LSU vs Arkansas Prediction, Picks, Spread, Odds for Football Matches, Where to Watch, TV Channel, Live Stream

No. 8 LSU travels to face Arkansas on Saturday night in one of the SEC’s most intriguing clashes during a loaded Week 8 schedule. The Tigers are coming off a big win over Ole Miss, which was a huge boon to their College Football Playoff hopes (according to Fanatics Sportsbook, the Tigers are currently given betting odds of +135 to make the CFP), while the Razorbacks had a bye to prepare for one of their biggest conference rivals.

LSU has won seven Golden Boot battles in the last eight years and is on a two-game winning streak, but each of the modern installments of this historic feud has been extremely close. The last four games between the two have ended in one possession, including Arkansas’ 16-13 overtime win in 2021 – its only win in the series since 2015.

That 2015 season was the last time LSU lost to Arkansas as an AP ranked team. The Razorbacks also stand in the way of LSU’s first 3-0 start to conference play since the historic 2019 season. Avid fans will remember that the Tigers were 15-0 that year en route to their first College Football Playoff National Championship in program history.

The Razorbacks are a major obstacle. They played close games against ranked teams like Oklahoma State and Texas A&M that season and finally broke through in Week 6 with a win against then-No. 4 Tennessee.

LSU vs. Arkansas: Need to know

LSU’s explosive passing attack by the numbers: Hey, did you know that LSU is really good in the passing game? If you haven’t, you’ve certainly missed the last few years. Quarterback Garrett Nussmeier is the latest in a long line of great signal callers to wear the purple and gold. He currently ranks at or near the top of the SEC in several key categories:

  • Matching touchdowns: 18 (1st in SEC)
  • Pass yards per game: 331.5 (2nd)
  • Setbacks: 254 (1st)
  • Consecutive games with more than two pass TDs: Seven

So this shows us that he is given a lot of opportunities and he is making the most of them. But he also gets help. LSU’s offensive line has given everything so far. Of Nussmeier’s 254 dropbacks, he was sacked just twice, making him the fewest among quarterbacks in the SEC. He also throws the ball to some pimples.

  • Kyren Lacy: He is currently tied for the lead in the SEC with six touchdowns
  • Aaron Anderson: Has three-plus receptions and 60-plus yards receiving in all six games this season
  • Mason Taylor: His 33 receptions lead all SEC tight ends

The only concern with LSU’s passing offense is that Nussmeier has been a bit careless with the ball lately. He has had back-to-back games with two interceptions and has thrown at least one pick in four of six starts so far, including both of LSU’s SEC games.

Sam Pittman turns things around: Pittman entered the 2024 season on the hot seat and has delivered surprising results so far that may have just changed his tune. Under Pittman, the Razorbacks are now 1-5 against top-10 opponents, but that one win came two weeks ago at home against No. 4 Tennessee. This was the program’s first win against an AP Top 5 team since 2007 against LSU and it ended a seven-game home losing streak against AP Top 5 teams.

Arkansas has never beaten two top-10 teams in a row, despite having 17 chances to do so throughout program history. This would certainly be a huge achievement for Pittman, who has the chance to achieve a few other things that haven’t been achieved in a long time. Arkansas hasn’t started 5-2 at home since 2016 and hasn’t started 4-0 at home since 2011.

Fascinating trench battle: LSU boasts one of the best offensive lines in the country, anchored by two All-American-caliber offensive tackles in Will Campbell and Emery Jones Jr. In fact, Campbell did it CBS Sports Midseason All-American Team. But these two will have their hands full against the Razorbacks. Defensive players Eric Gregory – who plays more interior defense and therefore may not be able to keep up with the tackles as often – and Landon Jackson have terrorized opposing backfields all season. The two combined for five sacks, nine total quarterback pressures and 8.5 tackles for a loss.

How to watch LSU vs. Arkansas live

Date: Saturday, Oct. 19 | Time: 7 p.m. ET
Location: Donald W. Reynolds Razorback Stadium – Fayetteville, Arkansas

TV: CBS | Live stream: CBSSports.com, CBS Sports App (Free)
Keep streaming Paramount+ with Showtime (try for free)

LSU vs Arkansas Prediction, Tips

Looking at each team’s offensive performance in conference play, one might shy away from the over. But looking at the match it shows that a decent number of points should be scored in this game and I didn’t want to go for the spread as it is extremely tight and I think the final score will go both ways could. LSU’s defense was good against Ole Miss, but overall it wasn’t great. Of particular concern is the fact that the Tigers have the fourth-worst rush defense in the SEC, which bodes well for Arkansas’ pairing of quarterback Taylen Green and running back Ja’Quinden Jackson. Conversely, this will be the best passing attack Arkansas has seen all year, and the Razorbacks’ secondary has looked suspect at times this year. Expect points. In fact, there are more of them than sports betting apps predict. Selection: Over 55.5 (-110)

All odds via Fanatics Sportsbook. Check out the latest Fanatics promo code to get in on the game.

SportsLine’s proven computer model calls for five upsets in Week 8 of college football. Visit SportsLine now to see them all, plus get spread picks for every game from the model that simulates every game 10,000 times.

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The 2025 Color Capsule from Sherwin-Williams

The 2025 Color Capsule from Sherwin-Williams

Sherwin-Williams just announced its color of the year — but with a twist. The company introduced its first color capsule of the year, which contains nine different shades.

“The one common theme that unites this year’s color capsule is vintage with a twist,” says Sue Wadden, head of color marketing at Sherwin-Williams. “The capsule feels very eclectic and is reminiscent of the 1970s, which is making a comeback in home and design, but we added a few modern tones to keep it feeling fresh and cheerful,” she tells me.

Additionally, Wadden says the capsule is unexpected and this fresh approach includes an entire capsule collection rather than focusing on a single color like Sherwin-Williams typically does each year.

“What I like most about the capsule collection is that there is something for everyone – it presents a diverse range of shades including eclectic, classic, feminine, warm and cool tones, but still feels balanced.”

Wadden walked me through the 9 colors of the Color Capsule of the Year.

Bosc pear

According to Wadden, Bosc Pear SW 6390 is a cinnamon-dusted gold shade that evokes luxurious organic tones reminiscent of bygone eras. “For homeowners looking for a hue to add to an accent wall, I recommend a very sophisticated gold/yellow tone that creates bold accents in the most impressive way.”

Purple plaster

According to Wadden, Mauve Finery SW 6282 is versatile enough to be used as a wall color or accent color and provides a refreshing, botanical vibe. “It’s a great choice to add to a room where you want a unique, colorful yet gentle look, but due to this color’s calming properties, it looks particularly great in bathrooms to create a spa-like environment. “

clove

“Clove SW 9605 borders on black and is an inviting brown that comforts and calms,” says Wadden, noting that she likes the idea of ​​painting all four walls this dark shade. “Although it is a dark and bold color, it offers the perfect balance between elegance and comfort.”

Grounded

According to Wadden, Grounded SW 6089 is a calming and versatile, intriguing brown that provides a sophisticated earth tone.

Sun bleached

“Situated somewhere between warm and cool, Sunbleached SW 9585 is a light neutral that will complement virtually any design,” explains Wadden.

Chartreuse

“Chartreuse SW 0073, a bright yellow-green, is versatile enough to be versatile and bright, as well as a cheerful color that is both historical and relevant,” says Wadden.

White snow

“White Snow SW 9541’s brilliant light reflectance value (90) is beautiful and pure,” says Wadden, noting that it is popular with design professionals looking to achieve a bright and airy result.

Rain cloud

According to Wadden, Rain Cloud SW 9639 is both rustic and sophisticated, and is a stormy and deep gray-blue hue that combines classic and modern design.

Malabar

“Soft and inviting, Malabar SW 9110 is a neutral sandy beige that pairs well with other warm tones,” Wadden says.

Color combinations

Wadden tells me that one of her favorite color combinations in the capsule is combining browns with whites, like grounded and sunbleached, to create a combination that feels elegant yet restful.

Another combination she loves is Rain Cloud and Chartreuse. “This combination may seem strange since we don’t usually mix blue and yellow together, but these two colors give a room a really fresh, light and bright feel,” she says.

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Karwa Chauth 2024 Greetings and HD Images for Free Online Download: Send WhatsApp messages, happy Karva Chauth wishes, quotes and wallpapers to celebrate the festival

Karwa Chauth 2024 Greetings and HD Images for Free Online Download: Send WhatsApp messages, happy Karva Chauth wishes, quotes and wallpapers to celebrate the festival

Karwa Chauth, also known as Karva Chauth, is an annual Hindu festival celebrated by married women across India, especially in the country’s northern states. The auspicious day celebrates the bond between husband and wife. Married women fast from sunrise to moonrise and pray for the long life, health and prosperity of their husbands. The festival symbolizes love, devotion and the well-being of married couples. On this day, married women observe a strict fast throughout the day, abstaining from food and water until they see the moon in the evening. Karwa Chauth 2024 will be celebrated on Sunday, October 20. As we celebrate Karwa Chauth 2024, we have compiled Happy Karwa Chauth 2024 Wishes, Greetings, Karva Chauth 2024 HD Wallpapers, Karwa Chauth 2024 Messages and Karwa Chauth Images which you can download online for free and share with your family and friends . You can also share these Happy Karwa Chauth 2024 wishes to your partner to express your love on this special day.

Karwa Chauth is considered as a day to express one’s love and devotion towards one’s husband. A married woman observes a strict fast for the long life of her husband. The festival strengthens the emotional bond between men and women. While breaking the fast, women look through a sieve at the moon and then at their husbands, symbolizing filtering out any negativity and focusing only on purity and prosperity. It is a moment of shared tradition in which husbands also enthusiastically participate, helping their wives during Lent and often giving them the first bite of food to break their fast. Celebrate the auspicious day by sharing these Happy Karwa Chauth 2024 Greetings, Messages, HD Images, Quotes and Wallpapers.

Greetings from Karwa Chauth (Image Credit: File Image)

WhatsApp message reads: Fasting for love, praying for togetherness. Happy Karwa Chauth!

Greetings from Karwa Chauth (Image Credit: File Image)

WhatsApp message reads: On this Karwa Chauth night, may the clink of your bangles and the colors of mehendi bring you good luck! Happy Karwa Chauth.

Greetings from Karwa Chauth (Image Credit: File Image)

WhatsApp message reads: I hope this day strengthens the bond of love between us. May the Almighty bless us with a happy and long married life. Happy Karwa Chauth.

Greetings from Karwa Chauth (Image Credit: File Image)

WhatsApp message reads: I see you and my fast is ended. There is a moon in the sky and one in front of me. I couldn’t have asked for more. Thank you, dear, for all your love.

Greetings from Karwa Chauth (Image Credit: File Image)

WhatsApp message reads: Wishing you wonderful, happy moments with your loved ones on this auspicious day of Karwa Chauth.

On Karwa Chauth, women pray to Goddess Parvati for the long life of their husbands and ask for protection of their marriage. We wish you a happy Karwa Chauth!

(The above story first appeared on LatestLY on October 18, 2024 09:00 AM IST. For more news and updates on politics, world, sports, entertainment and lifestyle, log on to our website Latestly.com.)

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Watch the video for the new single

Watch the video for the new single

BLACKPINK’s Rosé is embarking on her next chapter as a soloist and has brought along Bruno Mars to kick things off in style. The two shared their fun new collaboration titled “APT.” with a music video co-directed by Mars. Stream the song below.

“SUITABLE.” offers a first look at Rosé’s upcoming solo album, titled Rosiewhich is due to arrive on December 6th. The 12-track project is described as her “most personal and open-hearted release to date” and she is responsible for writing credits on every song on the album.

The title of a song refers to a Korean drinking activity known as the apartment game. “It’s so simple, will put a smile on your face and break the ice at any party,” Rosé shared in a statement. “One evening in the studio I was teaching my crew how to play the game. Everyone was intrigued, especially when I started singing, so we played around with it and I said we should make a song out of it. Once Bruno joined the circuit, the rest became history!”

Bruno Mars confirmed the anecdote via Instagram. “I held on to that for dear life after Rosé introduced me to this Korean drinking game and made me sassy,” he said. “Soon after, she tried to kiss me and I said, ‘Woah, Rosie!’ What part of the game is this?’”

“What’s wrong with you,” Rosé replied.

While Rosé prepares for her album, Bruno Mars prepares for another leg of his Las Vegas residency (get tickets here). “SUITABLE.” marks another high-profile collaboration for Mars in 2024 following his previous single with Lady Gaga, “Die With a Smile.”

“SUITABLE.” Cover art:

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Randall County Inmate Dies in Jail Cell, Texas Ranges Investigation

Randall County Inmate Dies in Jail Cell, Texas Ranges Investigation

The Texas Rangers are investigating the death of a Randall County inmate.

In response to questions from ABC7 NewsThe Randall County Sheriff’s Office said 30-year-old Bryan Austin Fields was found unresponsive in his cell around 4:30 a.m. Wednesday.

“Correctional officers immediately initiated life-saving measures,” said Sgt. Hillary Garcia. “Emergency medical services arrived shortly afterwards…Despite their efforts, Fields was pronounced dead.”

The cause of death was not disclosed.

Fields was booked into prison on March 16, 2023 for stalking.

According to court documents, Fields repeatedly engaged in “obscene communication” with a woman in February 2023.

Additional charges were filed in July 2023, including assault on a public servant and two counts of harassment by a person in a correctional/detention/civil detention facility.

He is accused of having his saliva “come into contact” with two correctional officers.

The charge of assault on a public servant was dismissed on August 31, 2023.

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Scammers extort $25,000 from elderly California man using AI voice technology to claim his son was in a ‘terrible accident’ and needed money for bail: ‘Absolutely his vote’

Scammers extort ,000 from elderly California man using AI voice technology to claim his son was in a ‘terrible accident’ and needed money for bail: ‘Absolutely his vote’

A California senior was scammed out of $25,000 by scammers using an AI voice that imitated his son to make him believe his loved one was in a “horrible accident” and needed money to get out to be released from prison.

The man, identified only as Anthony, said he received a call from his son telling him he hit a pregnant woman while driving and she was “taken to the intensive care unit,” according to ABC 7.

“It was his voice. It was absolutely his voice,” he told the outlet. “There was no doubt about it.”

The man, identified only as Anthony, said he received a call from a man he believed was his son. He said he hit a pregnant woman while driving and she was “taken to the intensive care unit.” ABC7

Anthony said that after a brief conversation – using his son’s AI-generated voice – the scammer hung up, but minutes later received a second call from a man claiming to be his son’s lawyer, Michael Roberts.

“He said, ‘You need to get $9,200 as quickly as possible if you want your son to get out of prison.’ Otherwise he has 45 days,” Anthony said.

Anthony was suspicious of the lawyer’s call and said he tried to call his son to check whether he needed the bail, but his call went to voicemail.

The worried father then went to his bank and told the teller that he needed a large sum of money to install solar panels – so as not to raise any unwanted questions about the situation.

After returning home, Anthony had his daughter call the lawyer again, who told them that an Uber would be coming by shortly to pick up the deposit.

Anthony said that after a brief conversation – using his son’s AI-generated voice – the scammer hung up, but minutes later received a second call from a man claiming to be his son’s lawyer, Michael Roberts. ABC7

Surveillance cameras outside his home show his daughter checking the Uber license plate and handing the money to the driver.

However, the scammers weren’t finished yet.

Shortly after the driver left, Anthony received another call, this time from a man named Mark Cohen, posing as another attorney in his son’s case, telling him that the pregnant woman had died and his son’s bail had been increased be.

“The bail has been increased. Mark Cohen says another $15,800 to $25,000,” Anthony said.

Fearing that his son desperately needs the money to get out of prison on bail, the worried father returns to the bank and repeats the entire process.

Surveillance cameras outside his home show his daughter checking the Uber license plate and handing the money to the driver. ABC7

After withdrawing more money from the bank and giving the second payment to another Uber driver, the calls stopped and Anthony wondered if his son had been released from prison.

While they waited, he said his daughter began researching the number online and finding out what he had been told and made a disheartening discovery.

“‘Dad, I hope I’m wrong. I think you just got scammed out of $25,000,” he recalled his daughter telling him.

Anthony said he was so worried about his son’s fate that it “didn’t even cross his mind” until he was cheated out of a large portion of his savings.

“I never had a chance to make a second call unless I told them, ‘Wait.’ I’m going to stop this whole thing for a minute. I want to talk to my son. “I don’t care if he’s in prison or where he is, I want to talk to my son.” You don’t think like that. You don’t,” he said.

The senior shared that the whole situation happened so “quickly” that he didn’t have time to wonder if he was being scammed.

“I look like an idiot. I feel like an idiot, but I don’t care,” Anthony said, explaining that he shared his story to help others raise awareness of this issue.

Detective Chelsea Saeger of the Los Angeles Police Department tThe old ABC 7 says that scammers have become “smarter and more sophisticated” in recent years.

Anthony said he was so worried about his son’s fate that it “didn’t even cross his mind” until he was cheated out of a large portion of his savings. ABC7

“They’re using social media and technology to create these very believable and convincing stories, and people really believe they’re talking to a grandchild or a government official,” Saeger said.

Although phone scams are nothing new, advances in technology – particularly in artificial intelligence and number blockers – have opened up a new playing field for scammers who are begging unsuspecting victims to steal their hard-earned money.

“You call, and when you answer and it’s a scammer, there’s silence,” Saeger explained.

“They want you to say ‘Hello’ or ‘Is anyone there?’ say. All they need is three seconds of your voice to input it into the AI ​​and clone it.”

Los Angeles Police Department Detective Chelsea Saeger told ABC 7 that scammers have become “smarter and more sophisticated” in recent years. ABC7

The detective also said fraudsters would go through “video posts” on social media to capture voices and clone them to use to defraud others.

Saeger told the outlet that the department is investigating what happened to Anthony and is investigating the drivers who picked up the money.

However, she revealed that Uber or Lyft drivers are usually not involved in the scam and are just hired to complete the task – completely unaware that they are even part of the scam.

Saeger said you should never send money to someone you don’t know.

If they claim to be a government agency or financial institution, these entities will never call and ask you to send money immediately.

She also shared that scammers may ask their victims to “deposit money into crypto ATMs or transfer money to crypto accounts,” which is a big red flag.

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What do we know about Israel’s assassination of Hamas’s mastermind and what happens next?

What do we know about Israel’s assassination of Hamas’s mastermind and what happens next?



CNN

More than a year after Hamas’ devastating attacks on Israel on October 7, the country’s military said on Thursday it had killed the man it believes was the main architect of that cross-border massacre – raising questions about the future of the war and the future of the war It is a militant group itself that has suffered one blow after another in recent months.

The death of Hamas leader Yahya Sinwar could represent a rare opportunity for a ceasefire, U.S. officials say – as Israel has killed several other senior Hamas commanders, including Ismail Haniyeh, the group’s former political leader, as well as leader of the militant group Hezbollah in Lebanon.

Hamas and Hezbollah are both part of an axis of militant groups backed by Iran.

In a recorded video message on Thursday, Israeli Prime Minister Benjamin Netanyahu said Sinwar’s death was “the beginning of the day after Hamas” but “the task ahead is not yet complete.”

Hamas has not yet commented on reports of its leader’s death.

Here’s what you need to know:

Since the Oct. 7 attacks, Israel has poured its resources into a fierce manhunt for Sinwar, declaring him the most wanted man in Gaza and a “dead man walking.” At one point, an Israeli military spokesman said the hunt “will not stop until he is captured, dead or alive.”

And U.S. officials believe the Israeli military came close a few times, even obtaining a video that purportedly showed Sinwar with several family members in a Gaza tunnel — but he kept slipping away. Previously, the Israeli military had surrounded Sinwar’s home and carried out an intensive attack on his hometown of Khan Younis, but was unable to find him.

This year-long search finally came to an unexpected end on Wednesday in Rafah, southern Gaza. Israeli forces were in the area during a routine military operation when they came under fire near a building, according to two Israeli sources familiar with the matter.

According to the Israeli military, troops returned fire with a tank and then flew a drone into the heavily damaged building. Video shared by the military shows Sinwar’s apparent final moments: he sits alone in a chair, surrounded by dust and debris, and appears to look directly into the camera. He holds a piece of wood and throws it at the drone before the video ends.

Only then and when troops inspected the rubble did they discover that Sinwar was among the bodies, according to the Israeli military.

Dental records and other biometric data helped Israel identify the Hamas leader, according to a U.S. official and former official familiar with the matter.

Sinwar was trying to flee to the north when he was killed, another Israeli military spokesman said Thursday. He was found with a gun and more than 10,000 Israeli shekels, the spokesman said.

Sinwar has long been a key player in Hamas, joining the militant group in the late 1980s and quickly rising through the ranks.

He was born in a refugee camp in Gaza after his family was expelled from the Palestinian village of Al-Majdal – now part of the Israeli city of Ashkelon – during the Arab-Israeli war.

As a student, Sinwar became an anti-occupation activist but was sentenced to multiple life sentences in Israel after being accused of orchestrating a murder. He served 23 years in prison before being released in a prisoner exchange in 2011.

Sinwar returned to Gaza and quickly made a name for himself within Hamas. He founded the group’s feared international intelligence arm, the Majd, and was known for using brutal force against anyone suspected of collaborating with Israel.

Some also viewed him as a pragmatic political leader: in 2017, Hamas elected Sinwar as political chief of the Politburo, its main decision-making body in Gaza.

Sinwar was designated a global terrorist by the U.S. State Department and the European Union in 2015 and has been sanctioned by the United Kingdom and France in recent years.

But after the October 7 attacks, he gained greater prominence as one of Israel’s main targets. Israeli officials called him the “face of evil” and “the butcher of Khan Younis.”

He became one of Hamas’s most senior leaders in August after the assassination of Ismail Haniyeh in Iran. Sinwar had not been seen since the October 7 attacks and likely survived Israel’s siege of Gaza by bunkering down in a vast network of underground tunnels.

Israel has publicly accused Sinwar of being the “mastermind” behind Hamas’ October 7 attack – although experts say he was likely one of several.

The attack was the deadliest attack on Israel in its history. Hamas and other Palestinian armed groups killed more than 1,200 people, mostly civilians, and took about 250 people hostage in Gaza.

Sinwar was considered a key decision-maker and probably the most important contact for the outside world in Gaza during the intensive negotiations over the return of the hostages.

Senior figures from Israel, Hamas, the United States, Qatar and Egypt took part in the talks.

While it is still too early to say what might happen next or how Hamas might respond, Sinwar’s killing marks the latest blow to the group – which has killed several top leaders one by one during Israel’s campaign to completely dismantle Hamas has.

Just a day after Haniyeh’s killing, Israel confirmed that it had killed Hamas military chief Mohammed Deif – another of the suspected masterminds of the October 7 attack – in an earlier attack.

With a ceasefire and hostage release agreement to end the war stubbornly stalled for months, senior U.S. officials had clung to hope that Sinwar could one day be defeated – paving the way to a resolution. With him now gone, officials speculate that this could be one of the best chances to end the war between Israel and Hamas, but are cautious about predicting what it will ultimately mean for the volatile region.

US President Joe Biden spoke to Netanyahu in a phone call on Thursday in which “both leaders agreed that there was an opportunity to move forward with the release of the hostages and that they would work together to achieve this goal.” said a reading from the Prime Minister’s Office.

But much remains unknown – including the fate of Sinwar’s brother.

Mohammed Sinwar recently took over as Hamas’ military commander, a senior Israeli official told CNN last month. The brothers were very close and were often still together until late August, the same official told CNN.

If Mohammed survives this week, he will likely continue his brother’s tough negotiating tactics as Israel tries to free its remaining hostages from the Palestinian enclave. But until a clear picture emerges, it will be difficult to see the militant group’s next move.

And even after Sinwar’s death, the broader Middle East conflict continues to rage – particularly as Israel prepares to retaliate against Iran’s ballistic missile attack earlier this month. CNN previously reported that this move was expected before the US election.

And beyond the Israeli-Lebanese border, another front of the conflict is emerging: Hezbollah announced on Thursday a “new and escalating phase” in its war with Israel.

Hezbollah has also suffered significant losses in recent months – from the deadly pager and walkie-talkie attacks that killed dozens and injured thousands, many of them civilians, to the assassinations of several senior commanders, including its boss Hassan Nasrallah last month.

Meanwhile, Palestinians in Gaza told CNN they do not believe Sinwar’s killing will end the war – although some expressed tentative hopes.

“Sinwar died, but so many of our people were killed and there is now no excuse for Netanyahu to continue the war,” said 22-year-old Mumen Khalili.

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Researchers create the first single cell atlas of prenatal human skin

Researchers create the first single cell atlas of prenatal human skin

For the first time, researchers have created a single-cell atlas of prenatal human skin to understand how skin forms and what goes wrong in disease.

Researchers at Newcastle University’s Wellcome Sanger Institute and their collaborators used single-cell sequencing and other genomic techniques to create the atlas and discover how human skin, including hair follicles, is formed. These findings could be used to create new hair follicles in regenerative medicine and skin transplants for burn victims.

In the study published today (October 16th) in NatureThe team also created a “mini-organ” made of skin in a shell with the ability to grow hair. Using the organoid, they showed how immune cells play an important role in scar-free skin repair, which could lead to clinical applications in preventing scarring after surgery or scar-free healing after injury.

As part of the Human Cell Atlas, which maps all cell types in the human body to transform the understanding of health and disease, researchers provide a molecular “recipe” for building skin and a new organoid model for studying congenital skin diseases.

The skin is the largest organ in the human body and measures an average of two square meters. It provides a protective barrier, regulates our body temperature and can regenerate. The skin develops in the sterile environment of the uterus, with all hair follicles formed before birth – after birth, a follicular cycle occurs, but no new follicles are formed. Before birth, the skin has the unique ability to heal without scarring.

It has been very difficult to study how human skin develops because animal models have key differences. As part of the Human Cell Atlas, a team of researchers is investigating how human skin is structured. By understanding how skin develops, where cells are located in space and time, and the role genetics plays, we can figure out how certain mutations cause congenital skin conditions such as blistering and flaky skin.

In this new study, researchers at Newcastle University’s Wellcome Sanger Institute and their collaborators created the first single-cell and spatial atlas of human prenatal skin.

The team used samples of prenatal skin tissue, which they broke down to examine individual cells in suspension as well as cells in the tissue. Scientists used state-of-the-art single-cell sequencing and spatial transcriptomics to analyze individual cells in space and time and the cellular changes that regulate the development of skin and hair follicles. They described the steps that describe how human hair follicles are formed and noted differences from mouse hair follicles.

Using adult stem cells, the researchers also created a skin “mini-organ” in a shell, a so-called organoid, with the ability to grow hair. They compared the molecular properties of skin organoids with prenatal skin and found that the skin organoid model was more similar to prenatal skin than adult skin.

The team found that blood vessels did not form in the skin organoid and prenatal skin. By adding immune cells called macrophages to the organoid, they discovered that the macrophages promote blood vessel formation, and the team performed 3D imaging to assess blood vessel formation in the tissue.

These immune cells are known to protect the skin from infections. However, this is the first time that macrophages play a key role in the formation of human skin during early development by supporting the growth of blood vessels. This offers the opportunity to improve the vascularization of other tissue organoids.

The team also analyzed differences in cell types between prenatal skin and adult skin. They show that macrophages play an important role in scar-free skin repair in prenatal skin, which could lead to clinical applications to prevent scar formation after surgery or injury.

As a result of this study, the team provides a molecular “recipe” for the structure of human skin and the formation of hair follicles. These findings could be used to create new hair follicles for regenerative medicine, such as skin transplants for burn victims or people with cicatricial alopecia.

The prenatal atlas of human skin will also be used to determine in which cells the genes known to cause congenital hair and skin diseases such as blistering and flaky skin are active or expressed. The researchers found that genes involved in these diseases are expressed in prenatal skin, meaning they originate in the uterus. The skin organoids created in this study provide a new, accurate model for studying these diseases.

Dr. Elena Winheim, co-first author from the Wellcome Sanger Institute, said: “With our prenatal atlas of human skin, we have provided the first molecular ‘recipe’ for making human skin and revealed how human hair follicles are formed before birth.” These findings have amazing clinical potential and could be used in regenerative medicine when offering skin and hair transplants, for example for burn victims or people with cicatricial alopecia.”

We are pleased to have created a skin organoid model that grows hair. We discovered a new, important role for immune cells in promoting blood vessel growth in developing skin tissue, which could help improve other organoid models. These immune cells, called macrophages, also appear to play a key role in scarless skin repair in prenatal skin. Our findings could inform clinical advances to prevent scarring after surgery.”

Dr. Hudaa Gopee, co-first author, Newcastle University

Professor Muzlifah Haniffa, co-lead author and interim head of cell genetics at the Wellcome Sanger Institute, said: “Our prenatal human skin atlas and organoid model provide the research community with freely available tools to study congenital skin diseases and explore the possibilities of regenerative medicine.” We do exciting advances in creating the Human Cell Atlas, understanding the biological steps of how humans are built, and studying what goes wrong in disease.”

Source:

Welcome Sanger Institute

Magazine reference:

Gopee, NH, et al. (2024). A prenatal skin atlas shows the immune regulation of human skin morphogenesis. Nature. doi.org/10.1038/s41586-024-08002-x.

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Pennsylvania College of Technology welcomes high school students from near and far to Build My Future | Open House News, sports, jobs

Pennsylvania College of Technology welcomes high school students from near and far to Build My Future | Open House News, sports, jobs

High school students watch a classmate use an excavator at one of the exhibits during the My Future Open House PA event on the Pennsylvania College of Technology campus. Dozens of area schools participated in the event, where high school students were able to gain hands-on experience with careers in the professions and ask questions of representatives from those fields during the job fair. DAVE KENNEDY/Sun Gazette

High school students make their way between exhibits during the “Build My Future” PA event on the Pennsylvania College of Technology campus. Dozens of area schools participated in the event, where high school students were able to gain hands-on experience with careers in the trades and ask questions of representatives from those fields during the job fair. DAVE KENNEDY/Sun Gazette

Williamsport High School students make their way between exhibits during the PA “Build My Future” open house on the Pennsylvania College of Technology campus. Dozens of area schools participated in the event, where high school students were able to gain hands-on experience with careers in the professions and ask questions of representatives from those fields during the job fair. DAVE KENNEDY/Sun Gazette

Cody Ross of Ross Construction Academy talks to students about carpentry during the PA “Build My Future” open house event on the Pennsylvania College of Technology campus. Dozens of area schools participated in the event, where high school students were able to gain hands-on experience with careers in the trades and ask questions of representatives from those fields during the job fair. DAVE KENNEDY/Sun Gazette

During the PA Build My Future open house on the Pennsylvania College of Technology campus, there were numerous exhibits showcasing the careers. Dozens of area schools attended the event, which helped expose students to various careers in the trades.

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What channel is Duke vs. FSU on tonight? Time, TV schedule to watch Friday’s college football game live

What channel is Duke vs. FSU on tonight? Time, TV schedule to watch Friday’s college football game live

A struggling Florida State squad is hoping it can turn its season around, starting with a matchup against Duke on Friday night.

After a bye week, the Seminoles (1-5) will once again hand the keys to the offense to quarterback Brock Glenn, who made his first start of the 2024 season on October 5th. In a 29-13 loss to Clemson, Glenn finished the game with 228 passing yards, two touchdowns and one interception.

The Blue Devils (5-1) won their first five games of the year before falling to Georgia Tech. Duke has a chance to end a 22-game losing streak against Florida State that dates back to 1992.

Here’s everything you need to know about Duke vs. FSU, including TV and streaming options for the game.

What channel is Duke vs. FSU on tonight?

  • TV channels: ESPN2
  • Live stream: Fubo

Duke vs. FSU will be broadcast nationally on ESPN2. The game can also be streamed on Fubo, which is currently offering a free trial.

For a limited time, you can get your first month of Fubo for just $59.99, a savings of $20. Stream ESPN, ABC, CBS, Fox, NBC and more than 200 top live TV and sports channels without cable. (On participating plans only. Taxes and fees may apply.)

Duke vs. FSU start time

  • Date: Friday, October 18th
  • Time: 7pm ET

Duke vs. FSU begins Friday, October 18th at 7 p.m. ET. The game will be played at Wallace Wade Stadium in Durham, North Carolina

Duke vs. FSU radio station

  • Radio station: SiriusXM channels 193, 371

You can listen to Duke vs. FSU live on SiriusXM. Coverage occurs on channels 193 (Duke broadcast) and 371 (FSU broadcast).

Get three months of SiriusXM for just $1. Listen to live NBA, NFL, MLB and NHL games, as well as NASCAR, college sports and more. Stay up to date with all the news and get all the analysis across multiple sports-specific channels.

2024 Duke football schedule

Date Opponent Time (ET)
August 30th Duke 26Elon 3
September 6th Duke 26Northwest 20 (2OT)
September 14th Duke 26UConn 21
September 21st Duke 45Middle Tennessee 17
September 28th Duke 21North Carolina 20
Oct. 5 Georgia Tech 24Duke 14
Oct 18 vs. Florida State 7 p.m
Oct 26 vs SMU 8 p.m
November 2nd in Miami (Florida) Still open
November 9th at NC State Still open
November 23rd vs. Virginia Tech Still open
November 30th at Wake Forest Still open

2024 FSU football schedule

Date Game Time (ET)/Result
August 24th Georgia Tech 24FSU 21
September 2nd Boston College 28FSU 13
September 14th Memphis 20FSU 12
September 21st FSU 14California 9
September 28th SMU42FSU 16
Oct. 5 Clemson 29FSU 13
Oct 18 at Duke 7 p.m
Oct 26 in Miami (Florida) 7 p.m
November 2nd against North Carolina Still open
November 9th at Notre Dame 7:30 p.m
November 23rd against Charleston Southern Still open
November 30th against Florida Still open

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