Louisville vs. SMU odds, spread, time: 2024 college football picks, Week 6 predictions using a proven model

The SMU Mustangs (4-1) will look to build on their impressive win over Florida State when they face the No. 22 Louisville Cardinals (3-1) on Saturday afternoon. SMU has been one of the most impressive offensive teams in the country, scoring 66 points against TCU two weeks ago before posting a 42-16 win over Florida State. Louisville suffers its first defeat of the season and falls back to then number 1. 16 Notre Dame in a 31-24 final last week. This will be the first meeting of these schools in 40 years.

Kickoff is scheduled for 12:00 p.m. ET on Saturday at L&N Federal Credit Union Stadium. The SportsLine consensus puts Louisville ahead by 6.5 points while the over/under is at 56.5 points. Before making any SMU-Louisville picks, check out the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, its top-rated college football picks against the spread have generated well over $2,000 in profits for $100 players. Plus, all top college football picks went a sizzling 6-0 in Week 5. Everyone who has followed it has seen strong results.

The model has SMU vs. Louisville in its sights. You can head over to SportsLine to check out the picks. Here are several college football betting lines for spread, money line, and over/under:

• Louisville vs. SMU Spread: Louisville -6.5
• Louisville vs. SMU over/under: 56.5 points
• Louisville vs. SMU Money Line: Louisville -246, SMU +198
• Louisville vs. SMU Picks: Find the picks here
• Louisville vs. SMU Streaming: FuboTV (Try Free)

Why Louisville Can Cover

Louisville is coming off its first loss of the season, but outscored Notre Dame 395-280 in that setback. The Cardinals committed three turnovers and allowed three sacks while being flagged six times, so those mistakes ultimately proved too much to bear. Texas Tech transfer quarterback Tyler Shough was outstanding for the Cardinals, completing 65% of his passes for 1,114 yards and 11 touchdowns.

Alabama transfer Ja’Corey Brooks has 22 receptions for 368 yards and four touchdowns, two of which came last week. Freshman running back Isaac Brown rushed for 245 yards and a touchdown, making Louisville a difficult team for oddsmakers to evaluate because of all these new players. The Cardinals have won 14 of their last 15 home games and are 5-1 in their last six conference games. See which team you should choose here.

Why SMU can cover

SMU is coming off its two most impressive games of the season and is on its way to blowout wins over TCU and Florida State. The Mustangs put up 66 points as they rushed for 238 yards and three scores in their win over the Horned Frogs. They were able to build on that performance with a 42-16 win over Florida State last week, as senior running back Brashard Smith recorded 129 rushing yards and a touchdown.

The Mustangs average 42.2 points per game and 419.4 yards per game, including more than 200 per game on both the ground and through the air. Defensively, they had three interceptions against Florida State and are tied for the FBS lead with 14 takeaways through five games. They are on a six-game away winning streak and have won a total of 13 of their last 15 games. See which team you should choose here.

How to make Louisville vs. SMU picks

The model has simulated SMU vs. Louisville 10,000 times and the results are in. The model leans forward and has also generated a point spread pick that hits in 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. SMU and which side of the spread hits 60% of the time? Visit SportsLine now to see which side of the SMU vs. Louisville spread you should jump on, all from the advanced computer model that has risen well over $2,000 compared to its top-rated college football spread picks since its inception is, and find out.